This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles.
This service is provided by laboratories of Computer Science & Engineering and Biochemistry & Molecular Biology at the Pennsylvania State University. It is supported by PHS grants R01 LM05773 and R01 LM05110 from the National Library of Medicine.