THE GAMMA CHAIN VARIANTS WITHOUT THE PROPER IDENTIFICATION OF THE GENE (GGAMMA OR AGAMMA) THAT IS MUTATED

Hb Name        Residue
Number		        Amino Acid
Substitution		        Mutation (mutations in
parentheses are presumed)		   
F-Texas-II 6(A3) Glu->Lys (GAG->AAG)
F-Alexandra 12(A9) Thr->Lys (ACA->AAA)
F-Ube 108(G10) Asn->Lys (AAT->AAA)



AN AGAMMA CHAIN VARIANT WITH A DELETION

Hb Name        Residue
Number		        Amino Acid
Substitution		        Mutation (mutations in
parentheses are presumed)		   
F-Mauritius 23(B5) Ala->0



THE AGAMMA CHAIN VARIANTS WITH TWO AMINO ACID REPLACEMENTS, ONE BEING AGAMMAT [75(E19)ILE->THR; ATA->ACA]

Hb Name        Residue
Number		        Amino Acid
Substitution		        Mutation (mutations in
parentheses are presumed)		   
F-Xinjiang 25(B7) Gly->Arg (GGA->CGA)
F-Fukuyama 43(CD2) Asp->Asn (GAC->AAC)
F-Forest Park 73(E17) Asp->Asn GAT->AAT
F-Yamaguchi 80(EF4) Asp->Asn (GAT->AAT)
F-Siena 121(GH4) Glu->Lys (GAA->AAA)
F-Charlotte See text
F-Sassari See text
F-Waynesboro See text

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.