Hb F-Siena	Agamma121(GH4)Glu->Lys; 75(E19)Ile->Thr

ELECTROPHORESIS		Hb FX moves slower than Hb A2 at alkaline pH
IEF		Not reported
CHROMATOGRAPHY		Not reported
CHAIN SEPARATION		Not reported
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAA->AAA at codon 121
NOTES		Found in an Italian baby; quantity in the heterozygote ~20% of total Hb

REFERENCES
1.		Carè, A., Marinucci, M., Massa, A., Maffi, D., Sposi, N.M., Improta, T., and Tentori, L.: Hemoglobin, 7:79, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.