VARIANTS OF THE GGAMMA CHAIN (single base changes)

Hb Name        Residue
       Amino Acid
       Mutation (mutations in
parentheses are presumed)
F-Malaysia 1(NA1) Gly->Cys (GGT->TGT)
F-Meinohama 5(A2) Glu->Gly (GAG->GGG)
F-Auckland 7(A4) Asp->Asn (GAC->AAC)
F-Albaicin 8(A5) Lys->Glu or Gln (AAG->CAG or GAG)
F-Heather 12(A9) Thr->Arg (ACA->AGA)
F-Catalonia 15(A12) Trp->Arg (TGG->CGG)
F-Melbourne 16(A13) Gly->Arg (GGC->CGC)
F-Fuchu 21(B3) Glu->Gln (GAA->CAA)
F-Saskatoon 21(B3) Glu->Lys GAA->AAA
F-Urumqi 22(B4) Asp->Gly (GAT->GGT)
F-Granada 22(B4) Asp->Val (GAT->GTT)
F-Cosenza 25(B7) Gly->Glu (GGA->GAA)
F-Oakland 26(B8) Glu->Lys (GAA->AAA)
F-Tokyo 34(B16) Val->Ile (GTC->ATC)
F-Austell 40(C6) Arg->Lys (AGG->AAG)
F-Veleta 40(C6) Arg->Gly AGG->GGG
F-Cincinnati 41(C7) Phe->Ser TTC->TCC
F-Lodz 44(CD3) Ser->Arg (AGC->CGC)
F-Kingston 55(D6) Met->Arg (ATG->AGG)
F-Sacromonte 59(E3) Lys->Gln AAA->CAA
F-Emirates 59(E3) Lys->Glu (AAA->GAA)
F-M-Osaka 63(E7) His->Tyr (CAT->TAT)
F-Clarke 65(E9) Lys->Asn (AAG->AAT or AAC)
F-Shanghai 66(E10) Lys->Arg (AAG->AGG)
F-Brooklyn 66(E10) Lys->Gln (AAG->CAG)
F-Minoo 72(E16) Gly->Arg (GGA->CGA)
F-Kennestone 77(EF1) His->Arg (CAC->CGC)
F-Marietta 80(EF4) Asp->Asn (GAT->AAT)
F-M-Fort Ripley 92(F8) His->Tyr CAC->TAC
F-Columbus-GA 94(FG1) Asp->Asn (GAC->AAC)
F-La Grange 101(G3) Glu->Lys (GAG->AAG)
F-Macedonia-II 104(G6) Lys->Asn AAG->AAC
F-Malta-I 117(G19) His->Arg CAT->CGT
F-Caltech 120(GH3) Lys->Gln (AAA->CAA)
F-Carlton 121(GH4) Glu->Lys (GAA->AAA)
F-Port Royal 125(H3) Glu->Ala (GAG->GCG)
F-Poole 130(H8) Trp->Gly (TGG->GGG)
F-Onoda 146(HC3) His->Tyr (CAC->TAC)

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.