Hb F-Onoda	Ggamma146(HC3)His->Tyr

ELECTROPHORESIS		Not reported
IEF		Hb FX moves between Hb F and Hb A
CHROMATOGRAPHY		Not reported
CHAIN SEPARATION		GgammaX = 35.9%; Ggamma = 33.5%; Agamma = 30.6%
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A
DNA ANALYSES		Not reported; presumed mutation CAC->TAC at codon 146
NOTES		Found in a Japanese baby; Hb FX 26.4% of total Hb or 35% of total Hb F; increased oxygen affinity; normal Bohr effect and cooperativity

REFERENCES

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.