Hb F-Oakland | Ggamma26(B8)Glu->Lys |
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ELECTROPHORESIS | Hb FX moves slightly slower than Hb C at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes from a cation exchange HPLC column behind Hb A | ||
CHAIN SEPARATION | GgammaX = 32.1%; Ggamma = 40.4%; Agamma = 27.5% | ||
STRUCTURE STUDIES | Digestion of gammaX chain with trypsin; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAA->AAA at codon 26 | ||
NOTES | Found in a newborn of Chinese-Black descent; Hb FX 32% of total Hb |
REFERENCES | |||
1. | Kleman, K., Lubin, B., Wilson, J.B., Kutlar, A., Webber, B.B., and Huisman, T.H.J.: Hemoglobin, 11:181, 1987. |