A Syllabus of Human Hemoglobin Variants (1996)

TABLE OF CONTENTS

• Introduction
• Variants of the Alpha Chain (single base changes)
• Variants of the Beta Chain (single base changes)
• Variants of the ^GGamma Chain (single base changes)
• Variants of the ^AGamma Chain (single base changes)
• Other Gamma Chain Variants
  • The Gamma Chain Variants Without Proper Identification of the Gene (^GGamma or ^AGamma) That is Mutated
  • An ^AGamma Chain With a Deletion
  • The ^AGamma Chain Variants With Two Amino Acid Replacements, One Being ^AGamma^T [75(E19)Ile->Thr; ATA->ACA]
• Variants of the Delta Chain (single base changes)
• Hemoglobins With More Than One Amino Acid Substitution in the Alpha Chain
• Hemoglobins With More Than One Amino Acid Substitution in the Beta Chain
• Hemoglobins With Elongated Chains Resulting From Single Base Pair Mutations or Frameshifts at the 3' End of Exon 3 or the 5' End of Exon 1 of the Alpha2- or the Beta-Globin Gene
• Hemoglobins With Shorter Polypeptide Chains Due to Deletions of One-to-Five Amino Acids
• Hemoglobins With Longer Polypeptide Chains Due to Inserted Residues
• Hemoglobins With Longer or Shorter Beta Chains Due to Deletions and Insertions of Certain Amino Acid Residues
• Hybrid Hemoglobins
• Addendum: Variants Reported in the Literature Since January 1996 through March 1996