ADDENDUM
Variants Reported in the Literature Since January 1996 Through March 1996

Hb Name		Residue Number		Amino Acid Substitution		Mutation (mutations in parentheses are presumed)
Alpha Chain Variants
Bois Guillaume		65(E14)		Ala->Val		(GCG->GTG)
Gouda		72(EF1)		His->Gln		CAC->CAA
Fuchu-I		72(EF1)		His->Tyr		(CAC->TAC)
Fuchu-II		97(G4)		Asn->His		(AAC->CAC)
Mosella		111(G18)		Ala->Thr		(GCC->ACC)
Saclay		133(H16)		Ser->Asn		(AGC->AAC)
Beta Chain Variants
Nakano		8(A5)		Lys->Met		(AAG->ATG)
Iraq-Halabja		10(A7)		Ala->Val		GCC->GTC
Uxbridge		20(B2)		Val->Gly		(GTG->GGG)
Aubenas		26(B8)		Glu->Gly		GAG->GGG
Karlsruhe		28(B10)		Leu->Met		CTG->ATG
Hinwil		38(C4)		Thr->Asn		ACC->AAC
J-Europa		62(E6)		Ala->Asp		(GCT->GAT)
Costa Rica		77(EF1)		His->Arg		(CAC->CGC)
Tsurumai		82(EF6)		Lys->Gln		(AAG->CAG)
Debrousse		96(FG3)		Leu->Pro		CTG->CCG
Alzette		104(G6)		Arg->Lys		(AGG->AAG)

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.