HBS WITH LONGER OR SHORTER BETA CHAINS DUE TO DELETIONS AND INSERTIONS OF CERTAIN AMINO ACID RESIDUESb

Hb Name        Residues        Deletions / Insertions   
72              73    74    75             76
Montreal beta72(E16)-beta76(E20) Ser---Ala-Arg-Cys-Gln---Ala-
 
96      97   98      99
Galicia beta96(FG3)-beta99(G1) Leu---Leu---Asp-
 
140   141   142   143   144   145
Birmingham beta140(H18)-beta145(HC2) Ala--------Gln--------Tyr-


b There are several abnormal Hbs mentioned in the literature with inserted or deleted amino acid residues that are extremely unstable or are not formed because the abnormal chain is unable to combine with its counterpart to form a functional Hb molecule. These anomalies are not listed here but are mentioned in the eighth edition of the Beta- and Delta-Thalassemia Repository (Hemoglobin, 19:213, 1995)

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.