Hb Fuchu-II	alpha97(G4)Asn->His

CONTACT		Central cavity at the alpha1beta1 region
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		No separation by IEF
CHROMATOGRAPHY		Hb X elutes in front of Hb A in cation exchange HPLC; alphaX elutes later than alphaA from a CM-cellulose column
STRUCTURE STUDIES		Digestion of alphaX chain with trypsin; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation AAC->CAC at codon 97; alpha2 or alpha1
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a healthy Japanese male
OTHER INFORMATION		The alphaX was ~25% of total alpha

REFERENCES
1.		Harano, T., Harano, K., Uehara, S., and Matsushita, K.: Hemoglobin, 19:389, 1995.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.