Hb Mosella	alpha111(G18)Ala->Thr

CONTACT		alpha1beta1 contact
HEMATOLOGY		Normal in heterozygotes
ELECTROPHORESIS		Hb X focuses between Hb A and Hb A1c on IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of alphaX+alphaA chains; separation of pep-tides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCC->ACC; alpha2 or alpha1
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Observed in a 35-year-old female from Luxembourg and in one of her daughters
OTHER INFORMATION		Quantity of Hb X ~20%

REFERENCES
1.		Wajcman, H., Blouquit, Y., Lahary, A., Soummer, A.M., Groff, P., Bardakdjian, J., Préhu, C., Riou, J., Godard, C., and Galactèros, F.: Hemoglobin, 19:281, 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.