Hb Nakano	beta8(A5)Lys->Met

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves faster than Hb A on IEF
CHROMATOGRAPHY		Hb X and Hb A separate on anion exchange HPLC columns; the betaX chain elutes ahead of betaA from a CM-cellulose column
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation AAG->ATG at codon 8
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a 46-year-old Japanese woman
OTHER INFORMATION		Quantity in the heterozygote 45.3%

REFERENCES
1.		Harano, K., Harano, T., Koide, G., and Akimaru, S.: Hemoglobin, 19:397, 1995.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.