VARIANTS OF THE AGAMMA CHAIN (single base changes)

Hb Name        Residue
       Amino Acid
       Mutation (mutations in
parentheses are presumed)
F-Macedonia-I 2(NA2) His->Gln CAT->CAG
F-Texas-I 5(A2) Glu->Lys (GAG->AAG)
F-Kotobuku 6(A3) Glu->Gly (GAG->GGG)
F-Pordenone 6(A3) Glu->Gln (GAG->CAG)
F-Calluna 12(A9) Thr->Arg (ACA->AGA)
F-Kuala Lumpur 22(B4) Asp->Gly (GAT->GGT)
F-Pendergrass 36(C2) Pro->Arg (CCA->CGA)
F-Cobb 37(C3) Trp->Gly (TGG->GGG)
F-Bonaire-GA 39(C5) Gln->Arg (CAG->CGG)
F-Woodstock 40(C6) Arg->Lys AGG->AAG
F-Beech Island 53(D4) Ala->Asp (GCC->GAC)
F-Jamaica 61(E5) Lys->Glu (AAG->GAG)
F-Iwata 72(E16) Gly->Arg (GGA->CGA)
F-Xin-Su 73(E17) Asp->His (GAT->CAT)
F-Sardinia (AgammaT) 75(E19) Ile->Thr ATA->ACA
F-Dammam 79(EF3) Asp->Asn (GAT->AAT)
F-Victoria Jubilee 80(EF4) Asp->Tyr (GAT->TAT)
F-Dickinson 97(FG4) His->Arg (CAT->CGT)
F-Hull 121(GH4) Glu->Lys GAA->AAA
F-Baskent 128(H6) Ala->Thr (GCT->ACT)
F-Jiangsu 134(H12) Val->Met (GTG->ATG)

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.