Variants Reported in the Literature Since January 1996 Through March 1996

Hb Name        Residue
       Amino Acid
       Mutation (mutations in
parentheses are presumed)
Alpha Chain Variants
Bois Guillaume 65(E14) Ala->Val (GCG->GTG)
Gouda 72(EF1) His->Gln CAC->CAA
Fuchu-I 72(EF1) His->Tyr (CAC->TAC)
Fuchu-II 97(G4) Asn->His (AAC->CAC)
Mosella 111(G18) Ala->Thr (GCC->ACC)
Saclay 133(H16) Ser->Asn (AGC->AAC)
Beta Chain Variants
Nakano 8(A5) Lys->Met (AAG->ATG)
Iraq-Halabja 10(A7) Ala->Val GCC->GTC
Uxbridge 20(B2) Val->Gly (GTG->GGG)
Aubenas 26(B8) Glu->Gly GAG->GGG
Karlsruhe 28(B10) Leu->Met CTG->ATG
Hinwil 38(C4) Thr->Asn ACC->AAC
J-Europa 62(E6) Ala->Asp (GCT->GAT)
Costa Rica 77(EF1) His->Arg (CAC->CGC)
Tsurumai 82(EF6) Lys->Gln (AAG->CAG)
Debrousse 96(FG3) Leu->Pro CTG->CCG
Alzette 104(G6) Arg->Lys (AGG->AAG)

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.