Hb Saclay | alpha133(H16)Ser->Asn |
---|
CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | No separation from Hb A except by IEF | ||
CHROMATOGRAPHY | Not reported; partial separation of alphaX and alphaA chains by perfusion chromatography on a Poros RI column | ||
STRUCTURE STUDIES | Tryptic digestion of AE-alphaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; electrospray analysis | ||
DNA ANALYSES | Not reported; presumed mutation AGC->AAC at codon 133; alpha2 or alpha1 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in an Algerian-Alsatian female | ||
OTHER INFORMATION | Abnormal Hb was 20% of total Hb |
REFERENCES | |||
1. | Wajeman, H., Promé, D., Riou, J., Mathis, M., Godart, C., Hurtrel, D., Préhu, C., Bardakkjian, J., Bridey, F., and Galactéros, F.: Abstract 48, Nouv. Rev. Fr. d'Hematol., 38:27, 1996. |