Hb Saint-Antoine	beta74(E18)-beta75(E19) Gly-Leu->0

HEMATOLOGY		Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS		No separation obtained at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		pCMB; digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported
FUNCTION STUDIES		Normal or nearly normal
STABILITY		Slightly unstable
OCCURRENCE		Found in a 25-year-old female of Mediterranean origin
OTHER INFORMATION		None

REFERENCES
1.		Najman, A., Duhamel, G., Andre, R., Buc, H., Wajcman, H., Labie, D., and Schapira, G.: Nouv. Rev. Fr. d'Hematol., 13:803, 1973.
2.		Wajcman, H., Labie, D., and Schapira, G.: Biochim. Biophys. Acta, 295:495, 1973.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.