Hb Zaïre	His-Leu-Pro-Ala-Glu- inserted between
	alpha116(GH4)Glu and alpha117(GH5)Phe

HEMATOLOGY		Normal; slight microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS		Hb X moves faster than Hb A at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of AE-alphaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; frameshift is suggested
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a 36-year-old Zaïrian patient
OTHER INFORMATION		Hb X 19% in the heterozygote; Hb X2 0.4%

REFERENCES
1.		Wajcman, H., Blouquit, Y., Vasseur, C., Le Querrec, A., Laniece, M., Melevendi, C., Rasore, A., and Galacteros, F.: Hum. Genet., 89:676, 1992.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.