Hb P-Congo	betadelta hybrid (beta through 22; delta from 116)

HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb S at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; it may be that the betadelta gene of Hb P-Congo is located between a delta and a beta gene; the hybrid gene may result from a non-homologous crossover between beta and delta genes
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in several families from the Congo
OTHER INFORMATION		Found in combination with Hb S

REFERENCES
1.		Lehmann, H. and Charlesworth, D.: Biochem. J., 119:43, 1970.
2.		Dherte, P., Lehmann, H., and Vandepitte, J.: Nature, 184:1133, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.