Hb Kenya	Agammabeta hybrid (Agamma through 81; beta from 86)

HEMATOLOGY		Normal in the heterozygote; elevation of Hb F (Ggamma Hb F)
ELECTROPHORESIS		Hb X moves slightly slower than Hb S at alkaline pH; about the same by IEF
CHROMATOGRAPHY		Hb X was isolated on DEAE-Sephadex or Amberlite IRC-50 columns
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by cation exchange chromatography or fingerprinting; amino acid analysis
DNA ANALYSES		Gene mapping has identified the expected 22.5 kb deletion
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in several families from Kenya, Uganda, and other countries near Lake Victoria in Africa
OTHER INFORMATION		Quantity in the heterozygote 6%; with Hb S 16-22%; found in combination with Hb S and Hb A2'; homogeneous distribution of Hb F in red cells

REFERENCES
1.		Huisman, T.H.J., Wrightstone, R.N., Wilson, J.B., Schroeder, W.A., and Kendall, A.G.: Arch. Biochem. Biophys., 153:850, 1972.
2.		Kendall, A.G., Ojwang, P.J., Schroeder, W.A., and Huisman, T.H.J.: Am. J. Hum. Genet., 25:548, 1973.
3.		Smith, D.H., Clegg, J.B., Weatherall, D.J., and Gilles, H.M.: Nature, 246:184, 1973.
4.		Kendall, A.G. and Ojwang, P.J.; E. Afr. Med. J., 51:434, 1974.
5.		Nute, P.E., Wood, W.G., Stamatoyannopoulos, G., Olweny, C., and Failkow, P.J.: Br. J. Haematol., 32:55, 1976.
6.		Ojwang, P.J., Nakatsuji, T., Gardiner, M.B., Reese, A.L., Gilman, J.G., and Huis-man, T.H.J.: Hemoglobin, 7:115, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.