Hb F-Kennestone	Ggamma77(EF1)His->Arg

ELECTROPHORESIS		Hb FX moves between Hb S and Hb C at alkaline pH
IEF		Not reported
CHROMATOGRAPHY		Hb FX can be isolated by DEAE-cellulose chromatography
CHAIN SEPARATION
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CGC at codon 77
NOTES		Found in a Caucasian newborn; quantity in the heterozygote: 25.3% of total Hb or 30.7% of total Hb F

REFERENCES
1.		Nakatsuji, T., Lam, H., and Huisman, T.H.J.: Hemoglobin, 7:267, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.