Hb F-Cincinnati	Ggamma41(C7)Phe->Ser

ELECTROPHORESIS		Hb FX did not separate from Hb F at alkaline pH
IEF		Hb FX did not separate from Hb F by IEF
CHROMATOGRAPHY		Not reported
CHAIN SEPARATION		GgammaX = 29.5%; Ggamma = 37%; Agamma = 33.5%
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		A TTC->TCC mutation at codon 41
NOTES		Found in a Caucasian newborn with cyanosis; baby became normal when Hb F disappeared after birth

REFERENCES
1.		Kholi-Kumar, M., Zwerdling, T., and Rucknagel, D.L.: Am. J. Hematol., 49:43, 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.