Hb F-Caltech	Ggamma120(GH3)Lys->Gln

ELECTROPHORESIS		Hb FX moves faster than Hb A
IEF		Not reported
CHROMATOGRAPHY		Hb FX can be isolated by DEAE- and CM-cellulose chromatography
CHAIN SEPARATION		AgammaT = 14%; GgammaX = 31%; Ggamma = 41%; Agamma = 14%
STRUCTURE STUDIES		Tryptic digestion of Hb FX; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation AAA->CAA at codon 120
NOTES		Found in an infant of French-Swedish-Hispanic extraction; the baby was also heterozygous for the AgammaT chain

REFERENCES
1.		Shelton, J.B., Shelton, J.R., Espinueva, Z., Huynh, V., Schroeder, W.A., and Powars, D.: Hemoglobin, 6:577, 1982.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.