Hb A2-Roosevelt	delta20(B2)Val->Glu

CONTACT		External
ELECTROPHORESIS		Hb X moves like Hb S at alkaline pH
IEF		Same
CHROMATOGRAPHY		Hb X can be isolated by DEAE-cellulose chromatography
STRUCTURE ANALYSIS		Proteolytic digestion of deltaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSIS		Not reported; presumed mutation GTG->GAG at codon 20
NOTES		Found in members of an Iraqi family

REFERENCES
1.		Rieder, R.F., Clegg, J.B., Weiss, H.J., Christy, N.P., and Rabinowitz, R.: Biochim. Biophys. Acta, 439:501, 1976.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.