Hb A2-Niigata	delta1(NA1)Val->Ala

CONTACT		Amino terminus; 2,3-DPG binding site
ELECTROPHORESIS		Not reported
IEF		Hb X moves anodic to Hb A2
CHROMATOGRAPHY		Hb X was discovered by cation exchange HPLC; Hb X elutes between Hb A and Hb A1c
STRUCTURE ANALYSIS		Tryptic digestion of deltaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSIS		Not reported; presumed mutation GTG->GCG at codon 1
NOTES		Found in three Japanese individuals

REFERENCES
1.		Harano, T., Harano, K., Kushida, Y., Ueda, S., and Kawakami, H.: Hemoglobin, 15: 335, 1991.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.