Hb A2-Coburg	delta116(G18)Arg->His

CONTACT		External
ELECTROPHORESIS		Hb X moves slightly faster than Hb S at alkaline pH
IEF		Not reported
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE ANALYSIS		Tryptic digestion of AE-deltaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSIS		Not reported; presumed mutation CGT->CAT at codon 116
NOTES		Found in a Sicilian family in association with beta-thal

REFERENCES
1.		Sharma, R.S., Williams, L., Wilson, J.B., and Huisman, T.H.J.: Biochim. Biophys. Acta, 393:379, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.