Hb Wien	beta130(H8)Tyr->Asp

CONTACT		Internal
HEMATOLOGY		Heinz body hemolytic anemia in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A by conventional techniques
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation TAT->GAT at codon 130
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in an Australian male and his daughter, and in a German male
OTHER INFORMATION		Quantity in the heterozygote ~25%

REFERENCES
1.		Kleihauer, E. and Betke, K.: Klin. Wschr., 50:907, 1972.
2.		Lorkin, P.A., Pietschmann, H., Braunsteiner, H., and Lehmann, H.: Acta Haematol., 51:351, 1974.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.