Hb Warwickshire	beta5(A2)Pro->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		A slowly-moving variant on paper and cellulose acetate at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; peptide analyses
DNA ANALYSES		Not reported; presumed mutation CCT->CGT at codon 5
FUNCTION STUDIES		Small decrease in oxygen affinity
STABILITY		Slightly unstable
OCCURRENCE		Found in a Scottish family
OTHER INFORMATION		Quantity in the heterozygote 31-38%

REFERENCES
1.		Wilson, C.I.D., Cave, R.J., Lehmann, H., Close, M., and Imai, K.: FEBS Lett., 176:331, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.