Hb Tigraye	beta79(EF3)Asp->His

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X has a mobility like Hb S; at acidic pH Hb X is located between Hb S and Hb C
CHROMATOGRAPHY		Hb X elutes behind Hb C by cation exchange HPLC; the betaX chain elutes before the betaA chain on a reversed phase HPLC column
STRUCTURE STUDIES		Not reported; identification by DNA analysis only
DNA ANALYSES		A GAC->CAC mutation at codon 79
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a healthy Ethiopian male
OTHER INFORMATION		Quantity in the heterozygote 39.4%

REFERENCES
1.		Molchanova, T.P., Postnikov, Yu.V., Gu, L-H., Prior, J.F., Raven, J.L., Bennett, J.A., and Huisman, T.H.J.: Hemoglobin, 17:247, 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.