Hb Tigraye | beta79(EF3)Asp->His |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; Hb X has a mobility like Hb S; at acidic pH Hb X is located between Hb S and Hb C | ||
CHROMATOGRAPHY | Hb X elutes behind Hb C by cation exchange HPLC; the betaX chain elutes before the betaA chain on a reversed phase HPLC column | ||
STRUCTURE STUDIES | Not reported; identification by DNA analysis only | ||
DNA ANALYSES | A GAC->CAC mutation at codon 79 | ||
FUNCTION STUDIES | Increased oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a healthy Ethiopian male | ||
OTHER INFORMATION | Quantity in the heterozygote 39.4% |
REFERENCES | |||
1. | Molchanova, T.P., Postnikov, Yu.V., Gu, L-H., Prior, J.F., Raven, J.L., Bennett, J.A., and Huisman, T.H.J.: Hemoglobin, 17:247, 1993. |