Hb Tampa	beta79(EF3)Asp->Tyr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote and the homozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves between Hb S and Hb F
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by reversed phase HPLC, fingerprinting, and cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAC->TAC at codon 79
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a 6-year-old Caucasian male; both parents have the trait and the child is homozygous for Hb X
OTHER INFORMATION		Quantity in the heterozygote 33%

REFERENCES
1.		Johnson, M.H., Jue, D.L., Patchen, L.C., Hartwig, E.C., Schneider, M.J., and Moo-Penn, W.F.: Biochim. Biophys. Acta, 623:119, 1980.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.