Hb Ta-Li	beta83(EF7)Gly->Cys

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; a polymer of Hb X moves between Hb E and Hb G; the tetramer does not separate from Hb A
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography; Hb X elutes after Hb A
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; performic acid; sequencing
DNA ANALYSES		Not reported; presumed mutation GGC->TGC at codon 83
FUNCTION STUDIES		Not reported
STABILITY		Slightly unstable; polymerization
OCCURRENCE		Found in members of a Chinese family living in Taiwan
OTHER INFORMATION		Quantity in the heterozygote 38-42%

REFERENCES
1.		Blackwell, R.Q., Liu, C-S., and Wang, C-L.: Biochim. Biophys. Acta, 243:467, 1971.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.