Hb Strasbourg | beta23(B5)Val->Asp |
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CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate completely by IEF; Hb X focuses ahead of Hb A | ||
CHROMATOGRAPHY | Hb X and Hb A could not be separated by routine chromatographic methods | ||
STRUCTURE STUDIES | Tryptic digestion; fingerprinting; amino acid analysis; sequencing by Edman degradation and Dansylation | ||
DNA ANALYSES | Not reported; presumed mutation GTT->GAT at codon 23 | ||
FUNCTION STUDIES | Increased oxygen affinity; normal Bohr effect; decreased cooperativity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Portuguese female from Northern Portugal | ||
OTHER INFORMATION | Quantity in the heterozygote ~40% |
REFERENCES | |||
1. | Garel, M.C., Blouquit, Y., Arous, N., and Rosa, J.: FEBS Lett., 72:1, 1976. | ||
2. | Forget, B.G., Hemoglobin, 1:879, 1977. | ||
3. | Cohen-Solal, M., North, M.L., Thillet, J., Albrecht-Ellmer, K., Garel, M.C., Blouquit, Y., and Rosa, J.: FEBS Lett., 90:286, 1978. |