Hb Strasbourg	beta23(B5)Val->Asp

CONTACT		Internal
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate completely by IEF; Hb X focuses ahead of Hb A
CHROMATOGRAPHY		Hb X and Hb A could not be separated by routine chromatographic methods
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; sequencing by Edman degradation and Dansylation
DNA ANALYSES		Not reported; presumed mutation GTT->GAT at codon 23
FUNCTION STUDIES		Increased oxygen affinity; normal Bohr effect; decreased cooperativity
STABILITY		Normal
OCCURRENCE		Found in a Portuguese female from Northern Portugal
OTHER INFORMATION		Quantity in the heterozygote ~40%

REFERENCES
1.		Garel, M.C., Blouquit, Y., Arous, N., and Rosa, J.: FEBS Lett., 72:1, 1976.
2.		Forget, B.G., Hemoglobin, 1:879, 1977.
3.		Cohen-Solal, M., North, M.L., Thillet, J., Albrecht-Ellmer, K., Garel, M.C., Blouquit, Y., and Rosa, J.: FEBS Lett., 90:286, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.