Hb South Milwaukee	beta105(G7)Leu->Phe

CONTACT		Internal
HEMATOLOGY		Erythrocytosis in the heterozygote
ELECTROPHORESIS		No separation by standard procedures or IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of AE-betaX+betaA chains; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CTC->TTC at codon 105
FUNCTION STUDIES		Increased oxygen affinity; normal Bohr effect; decreased cooperativity
STABILITY		Normal
OCCURRENCE		Found in 15 members of a family of English ancestry
OTHER INFORMATION		Some carriers require phlebotomy to relieve symptoms of chest pain, dizziness, and fatigue

REFERENCES
1.		Honig, G.R., Vida, L.N., Latorraca, R., and Divgi, A.B.: Am. J. Hematol., 34:199, 1990.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.