Hb Shanghai	beta131(H9)Gln->Pro

CONTACT		Internal; alpha1beta1 contact
HEMATOLOGY		Hemolytic anemia in the heterozygote; reticulocytosis
ELECTROPHORESIS		No separation of Hb X and Hb A by routine analyses
CHROMATOGRAPHY		No separation reported; the betaX and betaA chains separate by CM-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CAG->CCG at codon 131
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in members of a Chinese family
OTHER INFORMATION		Quantity in the heterozygote ~35%

REFERENCES
1.		Zeng, Y.T., Ren, Z.R., Chen, M.J., Zhao, J.Q., Qiu, X.K., and Huang, S.Z.: Br. J. Haematol., 67:221, 1987.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.