Hb Sendagi	beta42(CD1)Phe->Val

ALSO KNOWN AS		Warsaw
CONTACT		Heme contact
HEMATOLOGY		Moderate hemolytic anemia with reticulocytosis; Heinz bodies
ELECTROPHORESIS		No separation reported
CHROMATOGRAPHY		No separation by cation or anion exchange chromatography; betaX elutes ahead of betaA in reversed phase HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting and reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation TTT->GTT at codon 42
FUNCTION STUDIES		Decreased oxygen affinity
STABILITY		Unstable
OCCURRENCE		Found in a Japanese male and his daughter, and in a Polish-American family
OTHER INFORMATION		Quantity in heterozygotes estimated at 42-45% (reversed phase HPLC); metHb formation

REFERENCES
1.		Ogata, K., Ito, T., Kazaki, T., Dan, K., Nomura, T., Nozawa, Y., and Kajita, A.: Hemoglobin, 10:469, 1986.
2.		Honig, G.R., Telfer, M.C., Rosenblum, B.B., and Vida, L.N.: Am. J. Hematol., 32:36, 1989.
3.		Honig, G.R., Vida, L.N., Rosenblum, B.B., Perutz, M.F., and Fermi, G.: J. Biol. Chem., 265:126, 1990.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.