Hb Saint-Jacques	beta140(H18)Ala->Thr

CONTACT		Internal
HEMATOLOGY		Erythrocytosis in the heterozygote (PCV 0.56 l/l)
ELECTROPHORESIS		No separation obtained
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of betaX and betaA chains; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCC->ACC at codon 140
FUNCTION STUDIES		Increased oxygen affinity; normal Bohr effect
STABILITY		Normal
OCCURRENCE		Found in a 36-year-old Caucasian male living in France
OTHER INFORMATION		None

REFERENCES
1.		Rochette, J., Varet, B., Boissel, J.P., Clough, K., Labie, D., Wajcman, H., Bohn, B., Magne, P., and Poyart, C.: Biochim. Biophys. Acta, 785:14:1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.