Hb Sabine	beta91(F7)Leu->Pro

CONTACT		Heme contact
HEMATOLOGY		Hemolytic anemia in the heterozygote; reticulocytosis; Heinz bodies
ELECTROPHORESIS		Two Hb fractions move between Hb A2 and Hb S at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of tryptic peptides by cation exchange chromatography; amino acid analysis; thermolysin
DNA ANALYSES		Not reported; presumed mutation CTG->CCG at codon 91
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a 16-year-old Scottish-English-German female but not in her parents or siblings; also in a 7-year-old Yugoslavian boy but not in his parents
OTHER INFORMATION		Quantity in the heterozygote was estimated at 8%

REFERENCES
1.		Schneider, R.G., Ueda, S., Alperin, J.B., Brimhall, B., and Jones, R.T.: N. Engl. J. Med., 280:739, 1969.
2.		Mills, G.C., Alperin, J.B., Hill, F.L., and Henderson, R.J.; Biochem. Med., 5:212, 1971.
3.		Shaeffer, J.R., J. Biol. Chem., 248:7473, 1973.
4.		Bogoevski, P., Efremov, G.D., Kezic, J., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 7:195, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.