Hb Rush	beta101(G3)Glu->Gln

CONTACT		Internal; central cavity; alpha1beta2 contact
HEMATOLOGY		Mild hemolytic anemia in the heterozygote (PCV 0.35-0.36 l/l)
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH and at acidic pH; at alkaline pH two zones move between Hb A and Hb S
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of betaX chain; separation of peptides by fin-gerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->CAG at codon 101
FUNCTION STUDIES		Normal
STABILITY		Unstable; forms hybrid Hbs
OCCURRENCE		Found in three individuals in three generations of a Black family in the USA
OTHER INFORMATION		Quantity in the heterozygote 35%

REFERENCES
1.		Adams, J.G., III, Winter, W.P., Tausk, K., and Heller, P.: Blood, 43:261, 1974.
2.		Shih, D.T-b., Jones, R.T., Imai, K., and Tyuma, I.: J. Biol. Chem., 260:5919, 1985.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.