Hb Pierre-Bénite	beta90(F6)Glu->Asp

CONTACT		External
HEMATOLOGY		Erythrocytosis in the heterozygote (PCV 0.56 l/l)
ELECTROPHORESIS		No separations with standard techniques; IEF showed a double Hb A band
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of AE-beta chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAG->GAC or GAT at codon 90
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in members of a Caucasian family from Northern France
OTHER INFORMATION		Quantity in the heterozygote 40-47% (densitometry)

REFERENCES
1.		Baklouti, F., Giraud, Y., Francina, A., Richard, G., Favre-Gilly, J., and Delaunay, J.: Hemoglobin, 12:171, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.