Hb Palmerston North	beta23(B5)Val->Phe

CONTACT		Internal
HEMATOLOGY		Erythrocytosis in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A at alkaline pH; Hb X moves approximately like Hb F in IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; reversed phase HPLC; amino acid analysis; Dansyl-Edman degradation
DNA ANALYSES		Not reported; presumed mutation GTT->TTT at codon 23
FUNCTION STUDIES		Increased oxygen affinity; normal cooperativity
STABILITY		Slightly unstable
OCCURRENCE		Found in a 73-year-old female in New Zealand
OTHER INFORMATION		Quantity in the heterozygote 40%

REFERENCES
1.		Brennan, S.O., Williamson, D., Whisson, M.E., and Carrell, R.W.: Hemoglobin, 6:569, 1982.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.