Hb P-Galveston	beta117(G19)His->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (Hb X moves in the position of Hb S) but not at acidic pH
CHROMATOGRAPHY		Hb X and Hb A can be separated by both cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting or by cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CGC at codon 117
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in several Black families
OTHER INFORMATION		Quantity in heterozygotes 45-50%; found in combination with Hb S, with Hb C, and with beta-thal

REFERENCES
1.		Dherte, P., Lehmann, H., and Vandepitte, J.: Nature, 184:1133, 1959.
2.		Silvestroni, E., Bianco, I., and Brancati, C.: Nature, 191:292, 1961.
3.		Schneider, R.G., Alperin, J.B., Brimhall, B., and Jones, R.T.: J. Lab. Clin. Med., 73:616, 1969.
4.		Di Iorio, E.E., Winterhalter, K.H., Wilson, K., Rosenmund, A., and Marti, H.R.: Blut, 31:61, 1975.
5.		Huisman, T.H.J.: FEBS Lett., 94:68, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.