Hb Old Dominion	beta143(H21)His->Tyr

CONTACT		External; central cavity; 2,3-DPG binding site
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Not reported
CHROMATOGRAPHY		Hb X moves faster than Hb A in cation exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->TAC at codon 143
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Not reported
OCCURRENCE		Found in a young diabetic male
OTHER INFORMATION		Quantity in the heterozygote ~50%

REFERENCES
1.		Fairbanks, V., McCormick, D., Horn, A., Jones, R., Shih, D., Hoyer, J., Madden, B.J., and Kubik, K.: Blood, 86:647a (Suppl. 1), 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.