Hb Okayama | beta2(NA2)His->Gln |
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CONTACT | 2,3-DPG binding site | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A can be separated by IEF; Hb X moves as Hb A1c | ||
CHROMATOGRAPHY | Hb X was isolated by cation exchange chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CAA or CAG at codon 2 | ||
FUNCTION STUDIES | Slight increase in oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a diabetic Japanese male | ||
OTHER INFORMATION | Quantity in the heterozygote 47.4% |
REFERENCES | |||
1. | Harano, T., Harano, K., Shibata, S., Ueda, S., Mori, H., and Arimasa, N.: FEBS Lett., 156:20, 1983. |