Hb North Chicago	beta36(C2)Pro->Ser

CONTACT		alpha1beta2 contact
HEMATOLOGY		Erythrocytosis in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A at alkaline pH; separation is possible by IEF; excellent separation of betaX, betaA, and alpha by PAGE
CHROMATOGRAPHY		No separation reported; the betaX chain elutes after the normal alpha chain from a reversed phase HPLC column
STRUCTURE STUDIES		Tryptic digestion of the betaX chain; separation of the peptides by fingerprinting and by reversed phase HPLC; amino acid analysis; ion mass spectral analysis
DNA ANALYSES		Not reported; presumed mutation CCT->TCT at codon 36
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Discovered in members of a Black family
OTHER INFORMATION		None

REFERENCES
1.		Rahbar, S., Louis, J., Lee, T., and Asmerom, Y.: Hemoglobin, 9:559, 1985.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.