Hb Newcastle	beta92(F8)His->Pro

CONTACT		Heme contact; proximal histidine
HEMATOLOGY		Mild chronic anemia with Heinz bodies present after splenectomy
ELECTROPHORESIS		Hb X moves between Hb A and Hb A2 at alkaline pH
CHROMATOGRAPHY		Hb X can be isolated by DEAE-Sephadex chromatography; Hb X elutes between Hb A2 and Hb A
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CCC at codon 92
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a 67-year-old English female
OTHER INFORMATION		Quantity in the heterozygote not reported; metHb was not observed

REFERENCES
1.		Finney, R., Casey, R., Lehmann, H., and Walker, W.: FEBS Lett., 60:435, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.