Hb N-Timone	beta8(A5)Lys->Glu

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X has a lower pI than Hb N-Baltimore on IEF; Hb X and Hb A separate at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting on a reversed phase column; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation AAG->GAG at codon 8
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Discovered in a French-Italian family
OTHER INFORMATION		Quantity in the heterozygote not reported

REFERENCES
1.		Lena-Russo, D., Orsini, A., Vovan, L., Bardakdjian-Michau, J., Lacombe, C., Blouquit, Y., Craescu, C.T., and Galacteros, F.: Hemoglobin, 13:743, 1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.