Hb Muskegon | beta83(EF7)Gly->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves slower than Hb A at alkaline pH; slightly anodic to Hb S; Hb X moves between Hb S and Hb C at acidic pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; cyanogen bromide treatment; sequencing of CNBr peptide | ||
DNA ANALYSES | Not reported; presumed mutation GGC->CGC at codon 83 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a few members of an American family | ||
OTHER INFORMATION | None; quantity in the heterozygote not reported |
REFERENCES | |||
1. | Broxson, E.H., Hine, T.K., and Moo-Penn, W.F.: Hemoglobin, 17:85, 1993. |