Hb Moriguchi | beta97(FG4)His->Tyr |
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CONTACT | External; alpha1beta2 contact | ||
HEMATOLOGY | Normal in the heterozygote; no erythrocytosis | ||
ELECTROPHORESIS | Hb X and Hb A separate by IEF; no separation by standard techniques | ||
CHROMATOGRAPHY | Hb X and Hb A separate by anion exchange HPLC; the betaX and betaA chains separate by CM-cellulose chromatography | ||
STRUCTURE STUDIES | Tryptic digestion of the AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->TAC at codon 97 | ||
FUNCTION STUDIES | Slightly increased oxygen affinity; Bohr effect nearly normal | ||
STABILITY | Stable | ||
OCCURRENCE | Found in a diabetic Japanese female and her 27-year-old son | ||
OTHER INFORMATION | Quantity in the heterozygote ~50% |
REFERENCES | |||
1. | Ohba, Y., Imai, K., Kumada, I., Ohsawa, A., and Miyaji, T.: Hemoglobin, 13:367, 1989. |