Hb Monroe	beta30(B12)Arg->Thr

ALSO KNOWN AS		Kairouan
CONTACT		alpha1beta1 contact
HEMATOLOGY		Mild anemia with microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS		Hb X has not been found except in a minor Hb zone isolated by CM-cellulose chromatography
CHROMATOGRAPHY		None reported
STRUCTURE STUDIES		Not reported
DNA ANALYSES		An AGG->ACG mutation at codon 30; codon 30 (AGG) is divided by intron 1 as follows: ---CTT*AG<-IVS-I->G*CTG*CTG---. It is the last nt G of exon 1 that is changed to C
FUNCTION STUDIES		Not reported
STABILITY		Most unstable
OCCURRENCE		Found in a Black family and a North African woman born to a Libyan father and a Tunisian mother
OTHER INFORMATION		Found in a Black girl in combination with the promoter mutation A->G at position -29; this patient was transfusion dependent

REFERENCES
1.		Gonzalez-Redondo, J.M., Stoming, T.A., Kutlar, F., Kutlar, A., Hu, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 13:67, 1989.
2.		Vidaud, M., Gattoni, R., Stevenin, J., Vidaud, D., Amselem, S., Chibani, J., Rosa, J., and Goossens, M.: Proc. Natl. Acad. Sci. USA, 86:1041, 1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.