Hb Miyashiro	beta23(B5)Val->Gly

CONTACT		Internal
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A cannot be separated with routine electrophoretic procedures
CHROMATOGRAPHY		No detailed information available
STRUCTURE STUDIES		Fingerprinting; amino acid analysis; Dansyl-Edman degradation
DNA ANALYSES		Not reported; presumed mutation GTT->GGT at codon 23
FUNCTION STUDIES		Increased oxygen affinity; normal Bohr effect; decreased cooperativity
STABILITY		Unstable
OCCURRENCE		Found in members of a Japanese family
OTHER INFORMATION		Quantity in the heterozygote estimated at 29-38%

REFERENCES
1.		Nakatsuji, T., Miwa, S., Ohba, Y., Hattori, Y., Miyaji, T., Miyata, H., Shinohara, T., Hori, T., and Takayama, J.: Hemoglobin, 5:653, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.