Hb Lulu Island | beta107(G9)Gly->Asp |
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CONTACT | Internal | ||
HEMATOLOGY | Not available | ||
ELECTROPHORESIS | Hb X focuses slightly ahead of Hb A (IEF) | ||
CHROMATOGRAPHY | Hb X and Hb A partially separate by cation exchange HPLC; the betaX and betaA chains separate on a reversed phase HPLC column (elution order: betaX, betaA, delta, alpha) | ||
STRUCTURE STUDIES | Not done | ||
DNA ANALYSES | A GGC->GAC mutation at codon 107 | ||
FUNCTION STUDIES | Normal oxygen affinity | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in an East Indian female | ||
OTHER INFORMATION | The only carrier is compound heterozygous for Hb X and betao-thal (codon 15, TGG->TAG) |
REFERENCES | |||
1. | Gray, G.R., Manson, H.E., Gu, L-H., Leonova, J.Ye., and Huisman, T.H.J.: Am. J. Hematol., 50:26, 1995. |